國家衛生研究院 NHRI:Item 3990099045/10731
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10731


    Title: Establishment of salt-induced chronic kidney disease in stroke-prone spontaneously hypertensive rats (SHRSP) and its therapeutic effect of kefir-derived peptides oral administration
    Authors: Chen, YH;Chen, HL;Chen, CM
    Contributors: NHRI Graduate Student Program
    Abstract: The consequence of chronic high blood pressure is increasingly prevalence of chronic kidney disease (CKD) and cardiovascular organ injury, prevalence the high costs and poor outcomes of treatment are a significant health issue at clinical. In this study, hypothesis the Kefir-fermented product derived from milk protein (as a nature source) with the protection of the kidney function in management of salt-induced chronic kidney disease. Therefore, we used the salt-induced kidney disease in stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model. SHRSP rats at 50–60 weeks of age were orally administered kefir-derived peptides (KDP) for four weeks. The results of KDP have good performance of anti- hypertension effect, further studies of immunohistochemical staining and western blotting showed that salt-induced kidney failure significantly increased the protein levels of CD68, MCP-1, α-SMA and ET-1 under 1% NaCl drinking water induction. However, treatment with KDP significantly decreased macrophage infiltration marker CD68, MCP-1, α-SMA and ET-1 levels compared to those in mock group of salt-treated SHRSP rats (P<0.05). Moreover, the results demonstrated that KDP improved salt-induced impaired kidney function. The examination of kidney histopathology further showed that KDP administration significantly decreased salt-induced glomerulosclerosis, tubular damage, collagen deposition, interlobular arterial thickness (P<0.05). These conclusion suggested that KDP exerted potent protection against salt-induced chronic kidney disease and antihypertension in SHRSP rats. Therefore, kefir-derived peptides may represent a novel kidney protective agent in clinical use.
    Date: 2017-04
    Relation: The FASEB Journal. 2017 Apr;31(1, Suppl.):Meeting Abstract 855.12.
    Link to: http://www.fasebj.org/content/31/1_Supplement/855.12.abstract?sid=fc5f961c-1ac3-47c5-a5d9-b5a255a5f716
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000405986505297
    Appears in Collections:[Others] Conference Papers/Meeting Abstract

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