國家衛生研究院 NHRI:Item 3990099045/10212
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 856372      在线人数 : 529
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10212


    题名: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations
    作者: Seow, WJ;Matsuo, K;Hsiung, CA;Shiraishi, K;Song, M;Kim, HN;Wong, MP;Hong, YC;Dean Hosgood, H, 3rd;Wang, Z;Chang, IS;Ping Chung, L;An, SJ;Wang, P;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YT;Shu, XO;Kim, YC;Bassig, BA;Chang, J;Ho, JC;J
    贡献者: Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics;National Institute of Cancer Research
    摘要: To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1-DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalog of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumor mutation patterns, which could have important translational implications.
    日期: 2017-01
    關聯: Human Molecular Genetics. 2017 Jan;26(2):454-465.
    Link to: http://dx.doi.org/10.1093/hmg/ddw414
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000397066400018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85018291744
    显示于类别:[熊昭] 期刊論文
    [蕭金福] 期刊論文
    [張憶壽] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB28025329.pdf445KbAdobe PDF180检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈