國家衛生研究院 NHRI:Item 3990099045/10212
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10212


    Title: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations
    Authors: Seow, WJ;Matsuo, K;Hsiung, CA;Shiraishi, K;Song, M;Kim, HN;Wong, MP;Hong, YC;Dean Hosgood, H, 3rd;Wang, Z;Chang, IS;Ping Chung, L;An, SJ;Wang, P;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YT;Shu, XO;Kim, YC;Bassig, BA;Chang, J;Ho, JC;J
    Contributors: Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics;National Institute of Cancer Research
    Abstract: To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1-DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalog of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumor mutation patterns, which could have important translational implications.
    Date: 2017-01
    Relation: Human Molecular Genetics. 2017 Jan;26(2):454-465.
    Link to: http://dx.doi.org/10.1093/hmg/ddw414
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000397066400018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85018291744
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles
    [I-Shou Chang] Periodical Articles

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