國家衛生研究院 NHRI:Item 3990099045/10062
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    題名: Dual-compartmental transcriptomic+proteomic analysis of a marine endosymbiosis exposed to environmental change
    其他題名: Dual-compartmental transcriptomic plus proteomic analysis of a marine endosymbiosis exposed to environmental change
    作者: Mayfield, AB;Wang, YB;Chen, CS;Chen, SH;Lin, CY
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: As significant anthropogenic pressures are putting undue stress on the world's oceans, there has been a concerted effort to understand how marine organisms respond to environmental change. Transcriptomic approaches, in particular, have been readily employed to document the mRNA-level response of a plethora of marine invertebrates exposed to an array of simulated stress scenarios, with the tacit and untested assumption being that the respective proteins show a corresponding trend. To better understand the degree of congruency between mRNA and protein expression in an endosymbiotic marine invertebrate, mRNAs and proteins were sequenced from the same samples of the common, Indo-Pacific coral Seriatopora hystrix exposed to stable or upwelling-simulating conditions for one week. Of the 167 proteins down regulated at variable temperature, only 2 were associated with mRNAs that were also differentially expressed between treatments. Of the 378 differentially expressed genes, none were associated with a differentially expressed protein. Collectively, these results highlight the inherent risk of inferring cellular behavior based on mRNA expression data alone and challenge the current, mRNA-focused approach taken by most marine and many molecular biologists.
    日期: 2016-12
    關聯: Molecular Ecology. 2016 Dec;25(23):5944-5958.
    Link to: http://dx.doi.org/10.1111/mec.13896
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0962-1083&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000389133700009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84999025077
    顯示於類別:[林仲彥(1999-2005)] 期刊論文

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