國家衛生研究院 NHRI:Item 3990099045/9978
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    題名: Physicochemistry and cardiovascular toxicity of metal fume PM2.5: A study of human coronary artery endothelial cells and welding workers
    作者: Lai, CY;Lai, CH;Chuang, HC;Pan, CH;Yen, CC;Lin, WY;Chen, JK;Lin, LY;Chuang, KJ
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Occupational exposure to welding fumes causes a higher incidence of cardiovascular disease; however, the association remains unclear. To clarify the possible association, exposure assessment of metal fumes with an aerodynamic diameter of <2.5 mum (PM2.5) in welding and office areas was characterized in a shipyard in Taiwan. Cardiovascular toxicity caused by PM2.5 was determined in workers (in both the welding and office areas). Significant amounts of bimodal metal fume particles with count median diameters (CMDs) of 14.1~15.1 and 126.3~135.8 nm were produced in the shipyard. Metal fume PM2.5 resulted in decreased cell viability and increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin (IL)-6, and nitric oxide (NO) in human coronary artery epithelial cells (HCAECs). We recruited 118 welding workers and 45 office workers for a personal PM2.5 exposure assessment and determination of urinary levels of 8-OHdG, 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), and various metals. We observed that a 10-mug/m(3) increase in the mean PM2.5 concentration was associated with a 2.15% increase in 8-OHdG and an 8.43% increase in 8-iso-PGF2alpha in welding workers. Both 8-OHdG and 8-iso-PGF2alpha were associated with Fe and Zn in the urine. In conclusion, metal fume PM2.5 could increase the risk of cardiovascular toxicity after inhalation.
    日期: 2016-09
    關聯: Scientific Reports. 2016 Sep;6:Article number 33515.
    Link to: http://dx.doi.org/10.1038/srep33515
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383327800001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84988354568
    顯示於類別:[陳仁焜] 期刊論文

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