國家衛生研究院 NHRI:Item 3990099045/9939
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    题名: 5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility
    作者: Lin, YH;Kuo, CC;Lee, CM;Chou, CH;Chen, YH;Yeh, JF;Huang, CC;Hung, CS;Liu, LYD;Ho, YL;Wu, KK
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Background Ventricular remodeling following myocardial infarction (MI) is closely associated with cyclooxygenase-2 (COX-2) expression. 5-methoxytryptophan (5-MTP) was reported to control COX-2 expression. Objectives To investigeate the association between 5-MTP and post-MI left ventricular remodeling. Methods This prospective study enrolled 26 non-diabetic patients with first-time ST segment elevation myocardial infarction (STEMI), and 58 controls. Levels of 5-MTP, N-terminal of pro-brain natriuretic peptide (NT-proBNP), aminoterminal propeptide of type III procollagen, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 were measured at day 1, day 3, 3 months, 6 months, and 1 year post-MI. Echocardiography was performed during the acute stage (within 72 h) and 3 months, 6 months, and 1 year post-MI. Results The STEMI patients had a significantly lower plasma 5-MTP level at day 1 which reached a nadir at 3 months post-MI. The level of 5-MTP at day 3 post-MI was significantly correlated with the level of NT-proBNP 1 year post-MI, suggesting that the level of plasma 5-MTP in the early phase after MI may predict subsequent cardiac stress and failure. Receiver operating characteristic curve analysis revealed that plasma 5-MTP had the best area under the curve value to predict plasma NT-proBNP 1 year post-MI. Further analysis using net reclassification improvement and integrated discrimination improvement models confirmed that plasma 5-MTP at day 3 post-MI significantly improved the predictive power of each of the parameters. Conclusion In non-diabetic STEMI patients, plasma 5-MTP levels were associated with biomarkers of post-MI left ventricular remodeling and damage.
    日期: 2016-11-01
    關聯: International Journal of Cardiology. 2016 Nov 1;222:895-900.
    Link to: http://dx.doi.org/10.1016/j.ijcard.2016.07.293
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-5273&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000384698300181
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84981349676
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