國家衛生研究院 NHRI:Item 3990099045/9891
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    题名: Intake of phthalate-tainted foods and serum thyroid hormones in Taiwanese children and adolescents
    作者: Tsai, HJ;Wu, CF;Tsai, YC;Huang, PC;Chen, ML;Wang, SL;Chen, BH;Chen, CC;Wu, WC;Hsu, PS;Hsiung, CA;Wu, MT
    贡献者: National Institute of Environmental Health Sciences;Division of Biostatistics and Bioinformatics
    摘要: On April-May, 2011, phthalates, mainly Di-(2-ethylhexyl) phthalate (DEHP), were deliberately added to a variety of foodstuff as a substitute emulsifier in Taiwan. This study investigated the relationship between DEHP-tainted foodstuffs exposure and thyroid function in possibly affected children and adolescents. Two hundred fifty participants <18 years possibly exposed to DEHP were enrolled in this study between August 2012 and January 2013. Questionnaires were used to collect details on their past exposure to DEHP-tainted food items. Blood and urine samples were collected for biochemical workups to measure current exposure derived from three urinary DEHP metabolites using a creatinine excretion-based model. More than half of 250 participants were estimated to be exposed to DEHP-tainted foods found to exceed the recommend tolerable daily intake of DEHP established by the European Food Safety Authority (<50 mug/kg/day). The median daily DEHP intake (DDI) among those 250 participants was 46.52 mug/kg/day after multiple imputation. This value was ~10-fold higher than the current median DEHP intake (4.46 mug/kg/day, n = 240). Neither past nor current DEHP exposure intensity was significantly associated with serum thyroid profiles. Future studies may want to follow the long-term health effects of this food scandal in affected children and adolescents.
    日期: 2016-07-29
    關聯: Scientific Reports. 2016 Jul 29;6:Article number 30589.
    Link to: http://dx.doi.org/10.1038/srep30589
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380645500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84980413863
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