國家衛生研究院 NHRI:Item 3990099045/9861
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9861


    Title: The risk of peripheral arterial disease after parathyroidectomy in patients with end-stage renal disease
    Authors: Hsu, YH;Yu, HY;Chen, HJ;Li, TC;Hsu, CC;Kao, CH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: PURPOSE: The changes of the risk of peripheral arterial disease (PAD) in patients with end-stage renal disease after parathyroidectomy are scant. METHODS: We used a nationwide health insurance claims database to select all dialysis-dependent patients with end-stage renal disease aged 18 years and older for the study population in 2000 to 2006. Of the patients with end-stage renal disease, we selected 947 patients who had undergone parathyroidectomy as the parathyroidectomy group and frequency matched 3746 patients with end-stage renal disease by sex, age, years since the disease diagnosis, and the year of index date as the non-parathyroidectomy group. We used a multivariate Cox proportional hazards regression analysis with the use of a robust sandwich covariance matrix estimate, accounting for the intra-cluster dependence of hospitals or clinics, to measure the risk of peripheral arterial disease for the parathyroidectomy group compared with the non-parathyroidectomy group after adjusting for sex, age, premium-based income, urbanization, and comorbidity. RESULTS: The mean post-op follow-up periods were 5.08 and 4.52 years for the parathyroidectomy and non-parathyroidectomy groups, respectively; the incidence density rate of PAD in the PTX group was 12.26 per 1000 person-years, significantly lower than the data in the non-PTX group (24.09 per 1000 person-years, adjusted HR = 0.66, 95% CI = 0.46-0.94). CONCLUSION: Parathyroidectomy is associated with reduced risk of peripheral arterial disease in patients with end-stage renal disease complicated with severe secondary hyperparathyroidism.
    Date: 2016-06
    Relation: PLoS ONE. 2016 Jun;11(6):Article number e0156863.
    Link to: http://dx.doi.org/10.1371/journal.pone.0156863
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000377564000026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84975776046
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles

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