國家衛生研究院 NHRI:Item 3990099045/9738
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    题名: San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats
    其它题名: San Huang Shel Shin Tang β-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats
    作者: Yeh, YL;Ting, WJ;Kuo, WW;Hsu, HH;Lin, YM;Shen, CY;Chang, CH;Padma, VV;Tsai, Y;Huang, CY
    贡献者: Institute of Cellular and Systems Medicine
    摘要: BACKGROUND: San Huang Shel Shin Tang (SHSST) is a traditional herbal decoction used as a hepato-protective agent and is composed of Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (2:1:1 w/w). Beta-cyclodextrin (beta-CD) modification may potentially increase the solubility and spectral properties of SHSST. METHODS: In this research, the hepato-protective effects of unmodified SHSST, beta-CD modified SHSST complex (SHSSTc) and silymarin were evaluated in carbon tetrachloride (CCl4) induced acute hepatotoxicity in rats. RESULTS: SHHSTc (40 mg/kg/day) and silymarin (100 mg/kg/day) both decreased the CCl4-induced cirrhosis pathway-related transforming growth factor beta (TGF-beta) and apoptosis pathway-related caspase-8 protein expressions, but SHSST (40 mg/kg/day) did not reduce TGF-beta and caspase-8 significantly . Moreover, SHHSTc (40 mg/kg/day) enhanced the activation of insulin-like growth factor 1 receptor (IGF1R) mediated survival pathway than the silymarin (100 mg/kg/day) to protect the liver from damage induced by CCl4. CONCLUSIONS: beta-CD modification promotes hepato-protective effects of SHSST and reduces the required-dosage of the SHSST.
    日期: 2016-05-27
    關聯: BMC Complementary and Alternative Medicine. 2016 May 27;16:Article number 150.
    Link to: http://dx.doi.org/10.1186/s12906-016-1127-8
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000377072300003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84969932793
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