國家衛生研究院 NHRI:Item 3990099045/9728
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    题名: GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer
    作者: Hsu, CP;Chuang, HC;Lee, MC;Tsou, HH;Lee, LW;Li, JP;Tan, TH
    贡献者: Division of Biostatistics and Bioinformatics;Immunology Research Center
    摘要: Lung cancer is the leading cause of cancer death worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of total lung cancers; 40% to 60% of NSCLC patients die of cancer recurrence after cancer resection. Since GLK (also named MAP4K3) induces activation of NF-kappaB, which contributes to tumor progression, we investigated the role of GLK in NSCLC. GLK protein levels of 190 samples from pulmonary tissue arrays and 58 pulmonary resection samples from stage I to stage III NSCLC patients were studied using immunohistochemistry or immunoblotting. High levels of GLK proteins were detected in pulmonary tissues from NSCLC patients. Elevated GLK protein levels were correlated with increased recurrence risks and poor recurrence-free survival rates in NSCLC patients after adjusting for pathologic stage, smoking status, alcohol status, and EGFR levels. Thus, GLK is a novel prognostic biomarker for NSCLC recurrence.
    日期: 2016-07
    關聯: Oncotarget. 2016 Jul;7(27):41748-41757.
    Link to: http://dx.doi.org/10.18632/oncotarget.9410
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380942600063
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85010861041
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