國家衛生研究院 NHRI:Item 3990099045/9699
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9699


    Title: Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy
    Authors: Chao, TB;Li, CF;Lin, CY;Tian, YF;Chang, IW;Sheu, MJ;Lee, YE;Chan, TC;He, HL
    Contributors: National Institute of Cancer Research
    Abstract: AIM: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. MATERIALS & METHODS: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. RESULTS: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). CONCLUSION: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
    Date: 2016-06
    Relation: Future Oncology. 2016 Jun;12(12):1457-1467.
    Link to: http://dx.doi.org/10.2217/fon-2016-0071
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1479-6694&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000376261500004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84969945220
    Appears in Collections:[Others] Periodical Articles

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