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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/9680
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| Title: | TPH1 and 5-HTTLPR genes specifically interact in opiate dependence but not in alcohol dependence |
| Authors: | Wang, TY;Lee, SY;Chung, YL;Chen, SL;Li, CL;Chang, YH;Wang, LJ;Chen, PS;Chen, SH;Chu, CH;Huang, SY;Tzeng, NS;Hsieh, TH;Lee, IH;Chen, KC;Yang, YK;Hong, JS;Lu, RB |
| Contributors: | Center for Neuropsychiatric Research |
| Abstract: | Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed. |
| Date: | 2016-04 |
| Relation: | European Addiction Research. 2016 Apr:201-209. |
| Link to: | http://dx.doi.org/10.1159/000444676 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1022-6877&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000377991900004 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84964089220 |
| Appears in Collections: | [其他] 期刊論文
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