國家衛生研究院 NHRI:Item 3990099045/9606
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9606


    Title: Nonapnea sleep disorders and the risk of acute kidney injury: A nationwide population-based study
    Authors: Lin, HY;Chang, KT;Chang, YH;Lu, T;Liang, CJ;Wang, DC;Tsai, JH;Hsu, CY;Hung, CC;Kuo, MC;Lin, CS;Hwang, SJ
    Contributors: Division of Geriatric Research
    Abstract: Nonapnea sleep disorders (NASDs) and associated problems, which are highly prevalent in patients with kidney diseases, are associated with unfavorable medical sequelae. Nonetheless, whether NASDs are associated with acute kidney injury (AKI) development has not been thoroughly analyzed. We examined the association between NASD and AKI.We conducted a population-based study by using 1,000,000 representative data from the Taiwan National Health Insurance Research Database for the period from January 1, 2000, to December 31, 2010. We studied the incidence and risk of AKI in 9178 newly diagnosed NASD patients compared with 27,534 people without NASD matched according to age, sex, index year, urbanization level, region of residence, and monthly income at a 1:3 ratio.The NASD cohort had an adjusted hazard ratio (hazard ratio [HR]; 95% confidence interval [CI] = 1.15-2.63) of subsequent AKI 1.74-fold higher than that of the control cohort. Older age and type 2 diabetes mellitus were significantly associated with an increased risk of AKI (P < 0.05). Among different types of NASDs, patients with insomnia had a 120% increased risk of developing AKI (95% CI = 1.38-3.51; P = 0.001), whereas patients with other sleep disorders had a 127% increased risk of subsequent AKI (95% CI = 1.07-4.80; P = 0.033). Men with NASDs were at a high risk of AKI (P < 0.05).This nationwide population-based cohort study provides evidence that patients with NASDs are at higher risk of developing AKI than people without NASDs.
    Date: 2016-03
    Relation: Medicine. 2016 Mar;95(11):Article number e3067.
    Link to: http://dx.doi.org/10.1097/md.0000000000003067
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0025-7974&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000375211900052
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84962027400
    Appears in Collections:[Others] Periodical Articles

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