國家衛生研究院 NHRI:Item 3990099045/9588

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Title:	Immune tolerance and intolerance in IgG repertoires of hepatitis B carrier children
Authors:	Chang, YH;Kuan, HC;Hsieh, TC;Ma, KH;Yang, CH;Hsu, WB;Tsai, SF;Chao, A;Liu, HH
Contributors:	Institute of Molecular and Genomic Medicine
Abstract:	Background and Aim: This study aimed to implement sequence driven analyses of IgG repertoires to comprehend chronic hepatitis B infections and immune tolerance to vaccination. Methods: Repertoires were prepared from four carrier – noncarrier sibling pairs both before and 2 weeks after vaccination as sequence sets of the complementarity-determining region 3 (CDR3) on IgG heavy chains. Analyses were carried out in a framework shaped by both CDR3 clusters and diversity measures modeled from numerical ecology. Results: Carriers ’ repertoires clustered in principal component analysis (Fig. A). A huge set of related CDR3 clones presented almost exclusively among carriers (Fig. B). Vaccination increased CDR3 diversities among noncarriers (Fig. C), and tolerance at focused spectra of carriers ’ repertoires was distinguishable with post-vaccination clusters from noncarriers (Fig. D). Conclusion: Both vaccine tolerance and virus intolerance in children with chronic hepatitis B infections were distinct features strongly perceivable at perspectives of diversity measures and sequence clusters, demonstrating great potentials of immune repertoires in disease annotations.
Date:	2015-12
Relation:	Journal of Gastroenterology and Hepatology. 2015 Dec;30(Suppl. S4):23.
Link to:	http://dx.doi.org/10.1111/jgh.13186
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0815-9319&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000365677200054
Appears in Collections:	[Shih-Feng Tsai] Conference Papers/Meeting Abstract [Hong-Hsing Liu] Conference Papers/Meeting Abstract

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