國家衛生研究院 NHRI:Item 3990099045/9539
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9539


    Title: Curcumin ameliorates alveolar bone destruction of experimental periodontitis by modulating osteoclast differentiation, activation and function
    Authors: Mau, LP;Cheng, WC;Chen, JK;Shieh, YS;Cochran, DL;Huang, RY
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: This study evaluated as to whether curcumin (CCM) could ameliorate alveolar bone destruction in vivo and dissect its mechanism in vitro. The tartrate-resistant acid phosphatase (TRAP) activity, TRAP staining, quantitative RT-PCR, gelatin zymography, actin-ring formation, and pits formation assay were used to analyse the effect of CCM on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation, activation, and function. Porphyromonas gingivalis LPS- and ligature-induced experimental periodontitis were established to evaluate the therapeutic benefits of CCM in vivo. The results demonstrated that CCM dose dependently diminishes RANKL-induced osteoclast differentiation, and osteoclastic specific genes expression accompanied by a significant attenuation of actin-ring and resorptive pits formation in vitro. Moreover, CCM reduces alveolar bone destruction, decreases TRAP-positive and polymorphonuclear cells infiltration, and suppresses myeloperoxidase activity in vivo. Thus, CCM reduces inflammatory bone loss in vivo by modulating RANKL-mediated osteoclast differentiation, activation, and function.
    Date: 2016-04
    Relation: Journal of Functional Foods. 2016 Apr;22:243-256.
    Link to: http://dx.doi.org/10.1016/j.jff.2016.01.025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1756-4646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000372481900024
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961875617
    Appears in Collections:[Jen-Kun Chen] Periodical Articles

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