國家衛生研究院 NHRI:Item 3990099045/9513
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9513


    Title: Psychopathology, psychopharmacological properties, decision-making capacity to consent to clinical research and the willingness to participate among long-term hospitalized patients with schizophrenia
    Authors: Wu, BJ;Liao, HY;Chen, HK;Lan, TH
    Contributors: Center for Neuropsychiatric Research
    Abstract: Many studies discuss factors related to the decision-making capacity to consent to clinical research (DMC) of patients with schizophrenia. However, these studies rarely approached willingness to participate and the association between psychopharmacological properties (e.g., antipsychotic-induced side effects) and DMC. This study aimed to explore factors related to DMC and willingness to participate in patients with schizophrenia. All 139 patients with schizophrenia were assessed with the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) and other measures. A linear regression model was used to find the predictors of MacCAT-CR scores. A logistic regression model was used for exploring the predictors of willingness to participate. Patients with more severe negative symptoms performed poorly in DMC outcomes. In addition, females, those with fewer years of education and reduced cognitive function are more likely to experience difficulties in decision-making. Forty-three subjects (30.4%) chose to participate. Patients with higher level of positive symptoms, longer length of stay, higher burden of anticholinergics and users of atypical antipsychotics were more likely to participate in a clinical study which aimed to “enhance cognition”. These finding suggest that research investigators should consider many variables for patients who require more intensive screening for impaired DMC.
    Date: 2016-03
    Relation: Psychiatry Research. 2016 Mar;237:323-330.
    Link to: http://dx.doi.org/10.1016/j.psychres.2016.01.020
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0165-1781&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000371939300050
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84959222507
    Appears in Collections:[Others] Periodical Articles

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