國家衛生研究院 NHRI:Item 3990099045/9499
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9499


    Title: Cranioplasty using a novel osteoconductive scaffold and platelet gel
    Authors: Tseng, CL;Chang, GW;Ou, KL;Chou, WT;Wu, TH;Fang, HW;Tsai, JC;Chen, TM
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: BACKGROUND: Commonly used materials for cranioplasty include autogenous bone grafts, methyl methacrylate, and titanium mesh. We evaluated a novel osteoconductive scaffold [N-isopropylacrylamide cross-linked with acrylic acid using gamma-rays (ANa powder)] mixed with platelet gel for cranioplasty. METHODS: ANa powder mixed with platelet gel was implanted into a 15 x 15-mm, full-thickness calvarial bone defect in 5 New Zealand white rabbits. ANa powder mixed with phosphate-buffered saline was implanted in 5 rabbits. The calvarial bone defect was left unreconstructed in another 5 rabbits. Twelve weeks after surgery, computed tomography examination was used to evaluate the radiographic evidence of bone healing in vivo. Bone specimens were then retrieved for histologic study. RESULTS: The ANa scaffold mixed with platelet gel is biocompatible, biodegradable, and both osteoconductive and osteoinductive, leading to progressive growth of new bone into the calvarial bone defect. CONCLUSION: The use of this novel osteoconductive scaffold combined with osteoinductive platelet gel offers a valuable alternative for the reconstruction of calvarial bone defects.
    Date: 2016-03
    Relation: Annals of Plastic Surgery. 2016 Mar;76(Suppl. 1):S125-S129.
    Link to: http://dx.doi.org/10.1097/sap.0000000000000696
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0148-7043&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000375060000022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84955561138
    Appears in Collections:[Others] Periodical Articles

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