國家衛生研究院 NHRI:Item 3990099045/9449
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    題名: A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model
    作者: Sher, YP;Lin, SI;Chen, IH;Liu, HY;Lin, CY;Chiang, IP;Roffler, S;Chen, HW;Liu, SJ
    貢獻者: Division of Vaccine Research and Development
    摘要: Cancer immunotherapy is attractive for antigen-specific T cell-mediated anti-tumor therapy, especially in induction of cytotoxic T lymphocytes. In this report, we evaluated human CTL epitope-induced anti-tumor effects in human lung cancer xenograft models. The tumor associated antigen L6 (TAL6) is highly expressed in human lung cancer cell lines and tumor specimens as compared to normal lung tissues. TAL6 derived peptides strongly inhibited tumor growth, cancer metastasis and prolonged survival time in HLA-A2 transgenic mice immunized with a formulation of T-helper (Th) peptide, synthetic CpG ODN, and adjuvant Montanide ISA-51 (ISA-51). Adoptive transfer of peptide-induced CTL cells from HLA-A2 transgenic mice into human tumor xenograft SCID mice significantly inhibited tumor growth. Furthermore, combination of CTL-peptide immunotherapy and gemcitabine additively improved the therapeutic effects. This pre-clinical evaluation model provides a useful platform to develop efficient immunotherapeutic drugs to treat lung cancer and demonstrates a promising strategy with benefit of antitumor immune responses worthy of further development in clinical trials.
    日期: 2016-01
    關聯: Oncotarget. 2016 Jan;7(1):671-683.
    Link to: http://dx.doi.org/10.18632/oncotarget.6400
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000369950300050
    https://www.webofscience.com/wos/woscc/full-record/WOS:000369950300050
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