國家衛生研究院 NHRI:Item 3990099045/9442
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 924815      線上人數 : 954
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9442


    題名: Fabrication of keratin/fibroin membranes by electrospinning for vascular tissue engineering
    作者: Yen, KC;Chen, CY;Huang, JY;Kuo, WT;Lin, FH
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Cardiovascular diseases (CVDs) are some of the leading causes of death and bypass surgery is one of the common treatment options for the critical CVD patients. There is no ideal material available for arterial bypass surgery. Herein, a fibroin and keratin porous membrane was prepared by electro-spinning and proposed for tissue-engineered vascular grafts (TEVGs). The purified fibroin (F) and keratin (K) were mixed in different weight ratios of 9 : 1 (FK91), 8 : 2 (FK82), and 7 : 3 (FK73) to obtain a membrane. The SEM images revealed that the electro-spinned membranes have a fibrous interconnected porous structure. The average diameter of the membrane F, FK91, FK82 and FK73 was 5.74 +/- 1.04, 4.20 +/- 1.19, 2.94 +/- 0.81 and 2.27 +/- 0.65 [small mu ]m, respectively. The ultimate tensile strength (UTS) of F, FK91, FK82 and FK73 was 2.09 +/- 0.06, 2.02 +/- 0.06, 1.81 +/- 0.10 and 1.74 +/- 0.12 MPa, respectively. The contact angle of F, FK91, FK82 and FK73 was 72.55 +/- 0.55[degree], 66.39 +/- 0.90[degree], 43.47 +/- 0.04[degree] and 33.65 +/- 2.83[degree], respectively. The wettability results were in agreement with those of the cell adhesion to the electro-spinning membranes. The attached HUVECs on the developed membranes showed no cytotoxicity. The immunocytochemistry staining and qPCR analysis showed that the phenotype of the keratin-fibroin membrane was not altered. The results of the ultimate tensile strength, cell adhesion and microstructure revealed that FK82 is similar to native vessels and could be considered as a potential material for TEVGs.
    日期: 2016-01-14
    關聯: Journal of Materials Chemistry B. 2016 Jan 14;4(2):237-244.
    Link to: http://dx.doi.org/10.1039/C5TB01921D
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000367335200008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84952319172
    顯示於類別:[林峯輝] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    RSC2016010401.pdf4001KbAdobe PDF377檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋