國家衛生研究院 NHRI:Item 3990099045/9397
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    题名: An EGFR/Src-dependent beta4 integrin/FAK complex contributes to malignancy of breast cancer
    其它题名: An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer
    作者: Tai, YL;Chu, PY;Lai, IR;Wang, MY;Tseng, HY;Guan, JL;Liou, JY;Shen, TL
    贡献者: Institute of Cellular and Systems Medicine
    摘要: β4 integrin and focal adhesion kinase (FAK) are often associated with a poor prognosis in cancer patients, and their signaling events have recently been linked to malignant outcomes. Here, we demonstrate, for the first time, physical and functional interactions between β4 integrin and FAK that influence breast cancer malignancy. An amino-terminal linker within FAK is essential for its binding with the cytodomain of β4 integrin. Moreover, EGFR/Src-signaling triggers the tyrosine phosphorylation of β4 integrin, which, in turn, recruits FAK to β4 integrin and leads to FAK activation and signaling. Upon disruption of the β4 integrin/FAK complex, tumorigenesis and metastasis in triple-negative breast cancer were markedly reduced. Importantly, the concomitant overexpression of β4 integrin and FAK significantly correlates with malignant potential in patients with triple-negative breast cancer. This study describes a pro-metastatic EGFR/Src-dependent β4 integrin/FAK complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer.
    日期: 2015-11-09
    關聯: Scientific Reports. 2015 Nov 9;5:Article number 16408
    Link to: http://dx.doi.org/10.1038/srep16408
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000364297200001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946887740
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