國家衛生研究院 NHRI:Item 3990099045/9390
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 967186      線上人數 : 862
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9390


    題名: Direct x-ray luminescence tomography using selective plane illumination
    作者: Quigley, B;Cheng, SH;Souris, J;Chen, CT;Pelizzari, C;Kron, S;Lo, LW;La Riviere, P
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Objectives: The goal of this study is to develop a novel approach for imaging of lanthanide-based nanoparticles, which emit near-infrared light in response to stimulation with x-rays. Previous efforts to perform x-ray luminescence tomography have focused on first-generation tomographic geometries, acquiring a single line integral at a time [1,2]. Our goal here is to demonstrate that under conditions where light scattering is minimal, direct slice imaging can be achieved using illumination with a sheet beam coupled with detection using a conventional CMOS-based optical camera. This could provide a new means of monitoring response to radiation therapy or nanoparticle-enhanced radiation therapy. Methods: We synthesized europium doped yttrium oxide (Y2O3:Eu3+) nanophosphors. The x-ray source employed was an X_RAD 225Cx animal irradiator, which we modified with a slit collimator, allowing for creation of a sheet beam of x-rays. We used a Canon DSLR 5D Mark II with a F1.4 lens to acquire images of the stimulated illumination. The sample was scanned through the sheet beam and direct images of illuminated slices acquired. Results:We have established the feasibility of the idea as demonstrated in preliminary image data. We have also characterized the linearity of the nanophosphor luminescence with respect to x-ray fluence and their monotonically increasing luminosity with respect to x-ray voltage over a range of 25 to 225 keV. Conclusions:The use of selective plane x-ray illumination coupled with x-ray luminescent nanoparticles allows for direct tomographic imaging without the need to solve an ill-posed inverse problem. While the size and depth of objects that can be imaged by this technique is limited by scattering of the near-infrared light, this technique could allow sensitive imaging of superficial lesions and excised tissue specimens. Future work may allow imaging in larger specimens with modeling of scattering by exploiting the knowledge about the illumination geometry
    日期: 2014-05
    關聯: Journal of Nuclear Medicine. 2014 May;55(Suppl. 1):Abstract number 483.
    Link to: http://jnumedmtg.snmjournals.org/cgi/content/short/55/1_MeetingAbstracts/483
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0161-5505&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361438100484
    顯示於類別:[羅履維] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000361438100484.pdf71KbAdobe PDF466檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋