國家衛生研究院 NHRI:Item 3990099045/9387

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Title:	Mesoporous hydroxyapatite as olanzapine carrier provides a long-acting effect in antidepression treatment
Authors:	Shyong, YJ;Wang, MH;Tseng, HC;Cheng, C;Chang, KC;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	An antidepressant carrier was designed to maintain over 2 weeks of constant medication release. The carrier was injected into muscle, where cellular activity was employed to achieve the goal of constant release. Mesoporous hydroxyapatite (mesoHAP) was synthesized into an adequate size by a coprecipitation method; it then went through a series of hydrophobic surface modifications for olanzapine (OLZ) loading by physical absorption to produce mesoHAP-OLZ. Because of its hydrophobic nature, OLZ was not effectively released from mesoHAP-OLZ in an aqueous environment. However, once engulfed by macrophages, the lysosome/endosome hybrid ruptured due to alterations in osmotic pressure, resulting in the release of OLZ into the cytoplasm. OLZ was then exocytosed to the extracellular space due to a high calcium ion (Ca(2+)) concentration and finally reached the blood circulation. Our findings provide a useful treatment strategy to achieve long-term drug release with a single intramuscular (IM) injection, helping to solve the problem of nonadherent medication intake that often occurs in antidepressant therapy.
Date:	2015-11-12
Relation:	Journal of Medicinal Chemistry. 2015 Nov 12;58(21):8463-8474.
Link to:	http://dx.doi.org/10.1021/acs.jmedchem.5b00714
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000364796100009
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84947216814
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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