Prudent dietary pattern has been shown to correlate with reduced risks for renal dysfunction. To use folate as marker of prudent dietary pattern, we aimed to examine associations between plasma folate and impaired renal function as glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 in type 2 diabetes in Taiwan. Diabetic patients (n = 594) were selected from a cohort participating in a diabetic control study in Taiwan. Three dietary patterns, high fat, vegetable and fish and traditional Chinese snack, were generated using factor analysis. Plasma folate was classified as low (< 3 ng/ml), mid (3-5.9 ng/ml) and high (> 6 ng/ml) groups. Plasma folate correlated significantly with dietary factor scores of vegetable and fish pattern (p trend<0.001). After adjusting for confounders, mid- and low-levels of folate significantly associated with progressively (p trend < 0.05) higher risks of renal dysfunction (eGFR < 60 ml/min/1.73 m2). High fat and traditional Chinese snack patterns did not correlate with kidney function indicator. Plasma folate may serve as a valid dietary marker for prudent diets as frequent intake of fish and vegetable. Further prospective studies with larger sample size for studying early renal dysfunction in type 2 diabetes are needed to confirm this association.
Date:
2015-04
Relation:
FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number 758.3.
