國家衛生研究院 NHRI:Item 3990099045/9354
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    题名: Expression of the Helicobater pylori CagA protein is closely associated with Helicobater pylori-dependence of early-stage high-grade gastric lymphoma
    作者: Kuo, SH;Chen, LT;Lin, CW;Yeh, KH;Tsai, HJ;Tzeng, YS;Wu, MS;Hsu, PN;Cheng, AL
    贡献者: National Institute of Cancer Research
    摘要: Background: We have demonstrated that early-stage high-grade gastric lymphomas, including diffuse large B-cell lymphoma (DLBCL) with histologic evidence of mucosa-associated lymphoid tissue (DLBCL [MALT]) and DLBCL without MALT (“pure” DLBCL), may respond to Helicobater pylori eradication (HPE) therapy. Our recent data revealed that CagA expression is associated with HP-dependence of gastric MALT lymphoma. In this study, we further explore whether CagA expression is associated with the HP-dependence of high-grade gastric lymphoma. Material and Methods: Expression of CagA was evaluated by immunohistochemistry. CagA expression was further confirmed byWestern blot analysis. The association between CagA expression in malignant B-cells and tumor response to HPE was evaluated in 53 stage IE/IIE1 HP-positive high-grade gastric lymphoma patients. Tumors that had resolved to complete histological remission (pCR) score of GELA histological grading system after successful HPE were considered HP-dependent. Results: Between January 2003 and December 2013, a total 35 DLBCL(MALT) and 18 “pure” DLBCL patients who received HPE as frontline treatment were included. We detected CagA expression in 18 (51.4%) of 35 gastric DLBCL(MALT) and in 12 (66.7%) of 18 gastric “pure” DLBCL. CagA expression was higher in HP-dependent tumors than in HP-independent tumors (76.7% (23/30) versus 30.4% (7/23), P= 0.001). Patients with CagA expression responded to HPE quicker than those without (the median time to pCR, 2.3 months [95% CI, 2.08 to 2.52 months] versus 5.1 months [95% CI, 4.41 to 5.79 months], P= 0.021). Conclusions: Our results indicated that CagA can be detected in malignant B-cells of high-grade gastric lymphoma, and the expression of CagA is clinically and biologically associated with HP-dependence.
    日期: 2015-09
    關聯: European Journal of Cancer. 2015 Sep;51(Suppl. 3):S662.
    Link to: http://dx.doi.org/10.1016/S0959-8049(15)30061-7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0959-8049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361887403136
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