國家衛生研究院 NHRI:Item 3990099045/9349
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    题名: MiR-376c inhibits metastasis by controlling RUNX2-INHBA axis in oral squamous cell carcinoma
    作者: Chang, WM;Shiah, SG;Hsiao, M
    贡献者: National Institute of Cancer Research
    摘要: Aberrant microRNA expression is a common phenotype in cancer cell progression. MicroRNA is the negative regulator of hundred to thousand gene expressions. Here we report chr14q32.2 miRNA cluster significantly down-regulated in clinical OSCC samples. 19 miRNAs were found with coordinated silencing in OSCC patients. However, their specific target and regulation mechanism have not clearly identified. Here we showed miR-376c is the most significant microRNA down-regulated by RT-Q-PCR validation in the miRNA cluster. Ectopic expression of miR-376c not only inhibited oral cancer cells proliferation, but also migration and invasion. MiR-376c also inhibited the in vivo tumorigenesis and metastasis. Furthermore, miR-376c was found directly binding to the 3'-UTR of oncogenic transcription factor, RUNX2, which was found significantly up-regulated in OSCC patients. Silencing of RUNX2 inhibited OSCC proliferation and invasion through INHBA expression. Taken together, our study demonstrates the tumor suppressor role of miR-376c, which regulates RUNX2 transcriptomes in OSCC. Moreover, our results indicate RUNX2-INHBA axis may play important roles in OSCC progression.
    日期: 2015-04
    關聯: FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number 417.4.
    Link to: http://www.fasebj.org/content/29/1_Supplement/417.4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361470503117
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