國家衛生研究院 NHRI:Item 3990099045/9318
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9318


    Title: Nonapnea sleep disorders in patients younger than 65 years are significantly associated with CKD: A nationwide population-based study
    Authors: Lin, HY;Hung, CC;Chang, YH;Lin, MY;Yang, MY;Liang, SS;Liu, W;Chen, HC;Hwang, SJ
    Contributors: Division of Geriatric Research
    Abstract: BACKGROUND: Nonapnea sleep disorders (NASD) and sleep-related problems are associated with poor health outcomes. However, the association between NASD and the development and prognosis of chronic kidney disease (CKD) has not been investigated thoroughly. We explored the association between CKD and NASD in Taiwan. METHODS: We conducted a population-based study using the Taiwan National Health Insurance database with1,000,000 representative data for the period from January 1, 2000 to December 31, 2009. We investigated the incidence and risk of CKD in 7,006 newly diagnosed NASD cases compared with 21,018 people without NASD matched according to age, sex, index year, urbanization, region, and monthly income at a 1:3 ratio. RESULTS: The subsequent risk of CKD was 1.48-foldhigher in the NASD cohort than in the control cohort (95% confidence interval [CI] = 1.26-1.73, p< 0.001). Men, older age, type 2 diabetes mellitus, and gout were significant factors associated with the increased risk of CKD (p< 0.001). Among different types of NASDs, patients with insomnia had a 52% increased risk of developing CKD (95%CI = 1.23-1.84; P<0.01), whereas patients with sleep disturbance had a 49%increased risk of subsequent CKD (95% CI = 1.19-1.87; P<0.001). Younger women (aged < 65 years) were at a high risk of CKD with NASD (adjusted hazard ratio, [HR] = 1.81; 95% CI = 1.35-2.40, p< 0.001). CONCLUSIONS: In this nationwide population-based cohort study, patients with NASD, particularly men of all ages and women aged younger than 65 years, were at high risk of CKD.
    Date: 2015-10-14
    Relation: PLoS ONE. 2015 Oct 14;10(10):Article number e0140401.
    Link to: http://dx.doi.org/10.1371/journal.pone.0140401
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000363183100112
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84948947433
    Appears in Collections:[Others] Periodical Articles

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