國家衛生研究院 NHRI:Item 3990099045/9309

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Title:	Multiphysics modeling of liver tumor ablation by high intensity focused ultrasound
Authors:	Solovchuk, M;Sheu, TWH;Thiriet, M
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	High intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.
Date:	2015-10
Relation:	Communications in Computational Physics. 2015 Oct;18(4):1050-1071.
Link to:	http://dx.doi.org/10.4208/cicp.171214.200715s
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1815-2406&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000362974400011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84944383704
Appears in Collections:	[Maxim Solovchuk] Periodical Articles [Maxim Solovchuk] Periodical Articles

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