國家衛生研究院 NHRI:Item 3990099045/9244
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856151      線上人數 : 319
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9244


    題名: Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening
    作者: Wu, JS;Lin, SY;Liao, FY;Hsiao, WC;Lee, LC;Peng, YH;Hsieh, CL;Wu, MH;Song, JS;Yueh, A;Chen, CH;Yeh, SH;Liu, CY;Lin, SY;Yeh, TK;Hsu, JT;Shih, C;Ueng, SH;Hung, MS;Wu, SY
    貢獻者: Institute of Biotechnology and Pharmaceutical Research;Institute of Biomedical Engineering and Nanomedicine
    摘要: A structure-based virtual screening strategy, comprising homology modeling, ligand-support binding site optimization, virtual screening, and structure clustering analysis, was developed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhibitors. Compound 1 (IC50 = 711 nM), selected by virtual screening, showed inhibitory activity toward TDO and was subjected to structural modifications and molecular docking studies. This resulted in the identification of a potent TDO selective inhibitor (11e, IC50 = 30 nM), making it a potential compound for further investigation as a cancer therapeutic and other TDO-related targeted therapy.
    日期: 2015-10
    關聯: Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
    Link to: http://dx.doi.org/10.1021/acs.jmedchem.5b00921
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000362701600015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943744051
    顯示於類別:[伍素瑩] 期刊論文
    [洪明秀] 期刊論文
    [翁紹華] 期刊論文
    [石全(2014-2017)] 期刊論文
    [徐祖安] 期刊論文
    [葉燈光] 期刊論文
    [葉修華] 期刊論文
    [岳嶽] 期刊論文
    [林淑宜] 期刊論文
    [林書玉] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB26348881.pdf5030KbAdobe PDF649檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋