國家衛生研究院 NHRI:Item 3990099045/9235
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    题名: HMBD and 5-AzadC combination reverses tumor suppressor CCAAT/enhancer binding protein delta to strengthen the death of liver cancer cells
    作者: Wang, JM;Li, CF;Tsai, HH;Ko, CY;Pan, YC;Yen, CJ;Lai, HY;Yuh, CH;Wu, WC
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Hepatocellular carcinoma (HCC) can arise from chronic inflammation due to viral infection, organ damage, drug toxicity or alcohol abuse. Moreover, gene desensitization via aberrant CpG island methylation is a frequent epigenetic defect in HCC. However, the details of how inflammation linked with epigenetic-mediated desensitization of tumor suppressor genes remain less investigated. In this study, we found that loss of CEBPD enhances the growth of liver cancer cells and is associated with the occurrence of liver cancers, as determined by the assessment of clinical specimens and in vivo animal models. Moreover, E2F1-regulated epigenetic axis attenuated CEBPD expression in liver cancer cells. CEBPD is responsive to the hydroxymethyldibenzoylmethane (HMDB)-induced p38/CREB pathway and plays an important role in the HMDB-induced apoptosis of cancer cells. Regarding depression of epigenetic effects to enhance HMDB-induced CEBPD expression, the combination of HMDB and 5-Aza-2'-deoxycytidine (5-AzadC) could enhance the death of liver cancer cells and reduce the tumor formation of Huh7 xenograft mice. In conclusion, these results suggest that CEBPD could be a useful diagnostic marker and therapeutic target in HCC. The results also reveal the therapeutic potential for low-dose 5-AzadC to enhance the HMDB-induced death of HCC cells.
    日期: 2015-11
    關聯: Molecular Cancer Therapeutics. 2015 Nov;14(11):2623-2633.
    Link to: http://dx.doi.org/10.1158/1535-7163.mct-15-0025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1535-7163&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000364592000022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84958164701
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