國家衛生研究院 NHRI:Item 3990099045/9212
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    题名: Association of helicobacter pylori CagA translocation with the expression of CagA-signaling transduction molecules in gastric mucosa-associated lymphoid tissue lymphoma
    作者: Kuo, SH;Chen, LT;Lin, CW;Hsu, PN;Wu, MS;Tsai, HJ;Tzeng, YS;Yeh, KH;Cheng, AL
    贡献者: National Institute of Cancer Research
    摘要: Background: We previously reported that a direct contact of Helicobacter pylori (HP) with B cells results in CagA translocation into the latter, and the translocated CagA regulates intracellular signaling pathways. Toward this end, we recently found that CagA do exist in the malignant B cells of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and its presence is closely associated with HP-dependence. In this study, we further evaluate whether CagA expression regulates signaling transduction molecules in tumor cells of HP-positive gastric MALT lymphoma. Methods: Forty-seven patients of stage IE HP-positive gastric MALT lymphoma, who received HP eradication as their frontline therapy, were included. The expression of CagA, and its signaling pathway-related proteins, such as phosphorylated-SHP-2 (p-SHP-2), p-ERK, p-p38MAPK, Bcl-2, and Bcl-xL in tumor cells were evaluated by immunohistochemistry. Results: There were 25 HP-dependent and 22 HP-independent cases. Expression of CagA was closely associated with p-SHP-2 (P = .012), p-ERK (P =.002), p-p38MAPK (P = .006), Bcl-2 (P = .020, and Bcl-xL (P = .006) expression. Spearman’s correlation coefficient analysis showed the strong correlation between CagA-signaling transduction molecules. Combined CagA expression, p-SHP-2 expression and p-ERK expression showed an increased positive predictive value (93.3% [14/15] versus 81.8% [18/22]) and an increased specificity (95.5% [21/22] versus 81.8% [18/22]) for HP-dependence than CagA expression alone. Conclusions: Our results indicate that the expression of CagA protein is biologically active and is associated with activation of its downstream signals of HP-dependent gastric MALT lymphoma.
    日期: 2014-05
    關聯: Journal of Clinical Oncology. 2014 May;32(15, Suppl.):8571.
    Link to: http://meeting.ascopubs.org/cgi/content/abstract/32/15_suppl/8571
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000358613204250
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