國家衛生研究院 NHRI:Item 3990099045/9211
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 915716      在线人数 : 1234
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9211


    题名: Heterogeneous cell origin of helicobater pylori-dependent high-grade gastric lymphomas
    作者: Kuo, SH;Chen, LT;Lin, CW;Yeh, KH;Tsai, HJ;Lee, HW;Wu, MS;Hsu, PN;Cheng, AL
    贡献者: National Institute of Cancer Research
    摘要: Background: We recently showed that gastric “pure” diffuse large B-cell lymphoma (DLBCL) as well as DLBCL with histologic evidence of mucosa-associated lymphoid tissue (DLBCL[MALT]) remains Helicobater pylori (HP)-dependent, and can be cured by HP eradication (HPE) therapy. Since HP-related low-grade gastric lymphomas are of homogeneous marginal-zone B cell origin, we intended to explore if this holds true for HP-dependent high-grade gastric lymphoma. Methods: Lymphoma biopsies from 11 “pure’ DLBCL, 16 DLBCL(MALT), and 18 MALT lymphoma of stomach patients who achieved complete pathologic remission after HPE were included. We used immunohistochemistry to measure the expression of CD10, BCL6, and MUM-1, and used Hans algorithm to define germinal center B-cell (GCB) and non-GCB origin. Eight gastric “pure” DLBCLs were further examined by Agilent Whole Human Genome microarray to discriminate GCB and non-GCB signatures. Results: By Hans algorithm, all 18 low-grade MALT lymphomas were of non-GCB phenotype, compatible with marginal-zone B cell origin. Surprisingly, 7 (58.3%) of 12 gastric “pure” DLBCLs and 8 (50.0%) of 16 DLBCL (MALT)s were of GCB phenotype. By further gene expression assay in 8 cases of “pure” DLBCL, 4 (80.0%) of 5 patients with GCB by Hans algorithm had GCB signatures, whereas 2 (66.7%) of 3 patients with non-GCB by Hans algorithm had non-GCB signatures. Conclusions: These findings suggest that a substantial portion of HP-dependent large B-cell lymphoma of the stomach may not be of marginal B-cell origin. Whether HP can also transform GCB into large cell lymphoma warrants further investigation.
    日期: 2015-05
    關聯: Journal of Clinical Oncology. 2015 May;33(15, Suppl.):e19520.
    Link to: http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/e19520
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000358036904011
    显示于类别:[陳立宗] 會議論文/會議摘要
    [蔡慧珍] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000358036904011.pdf59KbAdobe PDF549检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈