國家衛生研究院 NHRI:Item 3990099045/9192
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9192


    Title: Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells
    Authors: Huo, C;Kao, YH;Chuu, CP
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Bone metastasis is very common in prostate cancer (PCa) and causes severe pain. PC-3 is an androgen receptor (AR)-negative high metastatic potential PCa cell line established from PCa bone metastasis. We observed that re-expression of AR, which locates in cytoplasmic in the absence of androgen, suppressed cell motility, migration, and invasion of PC-3 cells as determined by wound healing assay and transwell assay. Micro-Western Array and Western blotting analysis indicated that re-expression of AR increased APC, Akt2, Akt3, PI3K p85, phospho-PI3K p85 Tyr458, PI3K p85, and E-cadherin but decreased GSK-3β, phospho-GSK-3β Ser9, phospho-mTOR Ser2448, Skp2, NF-κB p50, Slug, N-cadherin, β-catenin, vimentin, MMP-9, and Snail. Migration and invasion of PC-3 and PC-3AR cells was promoted by EGF or IGF-1 but was suppressed by Casodex. Re-expression of AR reduced activity of MMP-2 and MMP-9 in PC-3 cells. Our observations suggested that re-expressing AR suppresses migration and invasion of PC-3 cells via regulation of EMT marker proteins and MMP activity.
    Date: 2015-12
    Relation: Cancer Letters. 2015 Dec;369(1):103-111.
    Link to: http://dx.doi.org/10.1016/j.canlet.2015.08.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3835&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000363819200013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943454601
    Appears in Collections:[Chih-Pin Chuu] Periodical Articles

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