國家衛生研究院 NHRI:Item 3990099045/9171
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9171


    Title: Use of nonsteroidal anti-inflammatory drugs and risk of chronic kidney disease in subjects with hypertension: Nationwide longitudinal cohort study
    Authors: Hsu, CC;Wang, H;Hsu, YH;Chuang, SY;Huang, YW;Chang, YK;Liu, JS;Hsiung, CA;Tsai, HJ
    Contributors: Division of Health Services and Preventive Medicine;Division of Biostatistics and Bioinformatics;Division of Geriatric Research
    Abstract: Limited studies have examined the effects of nonsteroidal anti-inflammatory drug (NSAID) use on the risk of chronic kidney disease (CKD), especially in subjects with hypertension. Using National Health Insurance claims data in Taiwan, we conducted a propensity score-matched cohort study to investigate the relationship between NSAID use and CKD in subjects with hypertension. A total of 31 976 subjects were included in this study: subjects not taking any NSAIDs in 2007 (n=10 782); subjects taking NSAIDs for 1 to 89 days in 2007 (n=10 605); and subjects taking NSAIDs for >/=90 days in 2007 (n=10 589). We performed multivariable proportional hazard models to determine the relationship between NSAID use and CKD. The results showed that NSAID use was associated with a 1.18-fold increased risk of CKD in subjects taking NSAIDs for 1 to 89 days; and a 1.32-fold increased risk of CKD in hypertension subjects taking NSAIDs for >/=90 days, compared with subjects not taking any NSAIDs, after controlling for the confounding factors. In subgroup analyses, subjects taking NSAIDs for >/=90 days, >1 defined daily dose per day or taking NSAIDs >15 cumulative defined daily doses had a greater risk of CKD than subjects not taking any NSAID, but not for congestive heart failure, stroke, cancer, osteoarthritis, or rheumatoid arthritis. These results provide supportive evidence that NSAID use is associated with increased risk of CKD in subjects with hypertension. It is important to closely monitor the effects of NSAID use, particularly in patients with hypertension, a susceptible population for CKD.
    Date: 2015-09
    Relation: Hypertension. 2015 Sep;66(3):524-533.
    Link to: http://dx.doi.org/10.1161/hypertensionaha.114.05105
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0194-911X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000359664700014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84939240143
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [Shao-Yuan Chuang] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Hui-Ju Tsai] Periodical Articles

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