國家衛生研究院 NHRI:Item 3990099045/9160
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    題名: BCAT1 overexpression is an indicator of poor prognosis in patients with urothelial carcinomas of the upper urinary tract and urinary bladder
    作者: Chang, IW;Wu, WJ;Wang, YH;Wu, TF;Liang, PI;He, HL;Yeh, BW;Li, CF
    貢獻者: National Institute of Cancer Research
    摘要: AIMS: Amino acid biosynthesis is one of the cardinal events of carcinogenesis that has not been investigated in urothelial carcinoma (UC). By data mining a published transcriptomic database of UCs of urinary bladder (UBUCs) (GSE31684), we identified branched-chain amino acid transaminase 1 (BCAT1) as the most significantly stepwise upregulated gene during tumor progression among those associated with amino acid biosynthetic process (GO:0008652). Accordingly, we analyzed BCAT1 transcript and protein expression with their clinicopathological significance. METHODS AND RESULTS: We used real time RT-PCR to detect BCAT1 transcript levels in 20 UCs of upper tract (UTUCs) and 20 UBUCs, respectively. Immunohistochemical study was performed to determine BCAT1 protein expression in 340 UTUCs and 295 UBUCs. Higher BCAT1 transcript levels were associated with higher pT status in both groups (p<0.05). BCAT1 protein overexpression was also significantly associated with adverse clinicopathological features, e.g., advanced pT stage, nodal metastasis, high pathological grade and etc. (p<0.05). BCAT1 overexpression predicted worse disease-specific survival and metastasis-free survival in both univariate and multivariate analyses (p</=0.001). CONCLUSION: BCAT1 overexpression is associated with advanced tumor status, and implies adverse clinical outcomes of UCs, suggesting its role in tumor progression and could serve as a prognostic biomarker and a novel therapeutic target in UC.
    日期: 2016-03
    關聯: Histopathology. 2016 Mar;68(4):520-532.
    Link to: http://dx.doi.org/10.1111/his.12778
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0309-0167&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000370080000007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84957942575
    顯示於類別:[其他] 期刊論文

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