國家衛生研究院 NHRI:Item 3990099045/9148
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    题名: Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice
    作者: Yeh, CW;Yeh, SHH;Shie, FS;Lai, WS;Liu, HK;Tzeng, TT;Tsay, HJ;Shiao, YJ
    贡献者: Center for Neuropsychiatric Research
    摘要: Although metabolic syndrome was suggested to be a risk factor for Alzheimer’s disease (AD), the role of metabolic stress in the initiation of AD pathology remains unclear. In this study, metabolic stress was induced by a high-fat diet and low-dose injection of streptozotocin (HFSTZ) prior to the appearance of senile plaques in APP/PS1 transgenic mice. We found that HFSTZ treatment exacerbated Aβ burden and astrocyte activation in the vicinity of plaques. Moreover, we observed an upregulation of astrocytic S100B expression in the brain parenchyma of HFSTZ-treated APP/PS1 mice concurrent with increased IL-6 expression in cerebral microvascular cells. To determine the impact of HFSTZ treatment on brain function, we performed [18F]FDG-positron emission tomography and analyzed nesting behavior. HFSTZ treatment impaired nest construction and cerebral glucose metabolism in several brain regions of APP/PS1 mice during the early stage of AD. These results suggest that HFSTZ-induced peripheral metabolic stress may contribute to vascular inflammation and astrocyte reactivity in the parenchyma and may impair activity of daily living skill and cerebral glucose metabolism in APP/PS1 mice.
    日期: 2015-11
    關聯: Neurobiology of Aging. 2015 Nov;36(11):2984-2994.
    Link to: http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.022
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0197-4580&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000363281700009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84947025276
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