The epidermis forms a critical barrier to defend against environmental insults. It is maintained by epidermal keratinocytes undergoing an orchestrated program of proliferation, differentiation, and death, which could be disrupted by gene mutations and cause skin diseases. Gasdermin A (GSDMA) is expressed in epithelial cells of the upper gastrointestinal tract, lung, and skin (1, 2). GSDMA is involved in apoptosis of the gastric epithelium cells (3) and has been linked with asthma susceptibility in genetic association studies (4). The function of GSDMA in the skin remains unclear. Among three GSDMA orthologs (Gsdma1-3) in mice, Gsdma1 and Gsdma3 are expressed in the differentiating keratinocytes of the epidermis.
