國家衛生研究院 NHRI:Item 3990099045/9132
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    题名: Biological evaluation of secondary metabolites from the root of machilus obovatifolia
    作者: Lin, SY;Ko, HH;Lee, SJ;Chang, HS;Lin, CH;Chen, IS
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Bioassay-guided fractionation of the root of Machilus obovatifolia led to the isolation of four new lignans, epihenricine B (1), threo-(7'R,8'R) and threo-(7'S,8'S)-methylmachilusol D (2 and 3), and isofragransol A (4), along with 23 known compounds. The compounds were obtained as isomeric mixtures (i.e., 2/3 and 4/20, resp.). The structures were elucidated by spectral analyses. Among the isolates, 1, licarin A (12), guaiacin (14), (+/-)-syringaresinol (21), and (-)-epicatechin (23) showed ABTS (=2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical-scavenging activity, with SC50 values of 11.7+/-0.5, 12.3+/-1.1, 11.0+/-0.1, 10.6+/-0.3, and 9.5+/-0.2 muM in 20 min, respectively. In addition, kachirachirol B (17) showed cytotoxicity against the NCI-H460 cell line with an IC50 value of 3.1 mug/ml.
    日期: 2015-07
    關聯: Chemistry and Biodiversity. 2015 Jul;12(7):1057-1067.
    Link to: http://dx.doi.org/10.1002/cbdv.201400196
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1612-1872&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000358143400006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946742634
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