國家衛生研究院 NHRI:Item 3990099045/9131
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    题名: The effects of phthalate and nonylphenol exposure on body size and secondary sexual characteristics during puberty
    作者: Hou, JW;Lin, CL;Tsai, YA;Chang, CH;Liao, KW;Yu, CJ;Yang, W;Lee, MJ;Huang, PC;Sun, CW;Wang, YH;Lin, FR;Wu, WC;Lee, MC;Pan, WH;Chen, BH;Wu, MT;Chen, CC;Wang, SL;Lee, CC;Hsiung, CA;Chen, ML
    贡献者: Division of Biostatistics and Bioinformatics;Division of Health Services and Preventive Medicine;National Institute of Environmental Health Sciences;Division of Health Policy Translation
    摘要: Background: Some phthalic acid esters (PAEs) and nonylphenol (NP) are endocrine-disrupting chemicals (EDCs) that are widely used in consumer products. Consequently, the general population is exposed simultaneously to both groups of chemicals. Objective: To investigate the single- and co-exposure effects of PAEs (DMP, DEP, DnBP, DiBP, BBzP, and DEHP) and NP on obesity and pubertal maturity to compare the body sizes of general adolescents with the complainants of the phthalate-tainted foods scandal that occurred in Taiwan. Methods: This study included 270 general adolescents aged 6.5-15.0 years and 38 complainants aged 6.5-8.5 years. Nine metabolites of the five PAEs and of NP were measured in urine. We used a questionnaire to evaluate pubertal maturity, measured anthropometric indices (APs) to assess body size, and collected urine samples to measure the two groups of chemicals. Results: We found that urinary PAE metabolite concentrations (specifically, metabolites of DEP, DnBP, DiBP, and DEHP) were positively associated with the APs for abdominal obesity (including skinfold thickness, waist circumference, waist-to-height ratio, and waist-to-hip) and indicated a dose-response relationship. Mono-methyl phthalate (MMP) exposure was inversely associated with pubarche among boys. The daily intake of DEHP in general adolescents exceeded the reference doses (RfD-20. μg/kg. bw/day) and tolerable daily intake (TDI-50. μg/kg. bw/day) by 3.4% and 0.4%, respectively. No associations were observed between NP exposure or co-exposure and the APs or pubertal maturity. No significant differences were observed between general adolescents and the complainants with regard to weight, height, or BMI. Conclusions: The study suggests that PAE (specifically, DEP, DnBP, DiBP, and DEHP) exposure is associated with abdominal obesity in adolescents and that the APs for abdominal obesity are more sensitive than BMI for measuring obesity among adolescents. We suggest that the RfD and TDI for PAEs should be revised to provide sufficient protection.
    日期: 2015-10
    關聯: International Journal of Hygiene and Environmental Health. 2015 Oct;218(7):603-615.
    Link to: http://dx.doi.org/10.1016/j.ijheh.2015.06.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1438-4639&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000375731300003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940605667
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