| Abstract: | 本發明係有關於一種用於抑制受到皰疹病毒屬感染的醫藥組成物，係具有如式(I)結構之化合物。其中R1及 R2分別為R或C(O)R；或R1及R2共同連結為(亞甲基)m； R3、R4及R5分別為R, OR, C(O)R,或OC(O)R；或R3，R4及R5中的任意2個共同連結為O(CH2)nO；Ar為芳香烴； Z1與Z2分別為亞甲基或C(O)；R6與R7分別為R, OR, SR,或NRR’；或R6與R7共同連結為氧，硫或NR；其中R與 R’分別為氫，烷基，(亞甲基)o-芳香烴，(亞甲基)p-雜芳香烴，環基，是雜環基；m及n分別代表1，2，3或4；o及p分別代表0，1，2，3，4，5或6。This invention features a medical composition for treating infection by herpesvirus. The composition includes an arylnaphthalene compound of formula (I). Each of R1 and R2, independently is R or C(O)R; or R1 and R2 taken together is (CH2)m; each of R3, R4, and R5, independently, is R, OR, C(O)R, or OC(O)R; or any two of R3, R4, and R5 taken together is O(CH2)nO; Ar is aryl; each of Z1 and Z2, independently, is CH2 or C(O); and each of R6 and R7, independently, is R, OR, SR, or NRR’; or R6 and R7 taken together is O, s, or NR; in which each of R and R’, independently, is H, alkyl, (CH2)o-aryl, (CH2)p-heteroaryl, cyclyl, or heterocyclyl; each of m and n, independently, is 1, 2, 3, or 4; and each of o and p, independently, is 0, 1, 2, 3, 4, 5, or 6. |
