本發明係有關於一種新穎之丹參酮吲哚啶生物鹼化合物,以及其於癌症之應用;本發明亦包括利用丹參酮吲哚啶生物鹼化合物以抑制NO與TNF-α之製造,抑制MEKK1活性與環氧酶II之表現,以及抑制與NO相關疾病之方法。A group of novel phenanthroindolizidine alkaloid compounds as shown and their use in treating cancer. Also disclosed are methods of using phenanthroindolizidine alkoid compounds in suppressing NO and TNF-α production, inhibiting MEKK1 activity and cyclooxygenase II expression, and treating NO-related disorders.