國家衛生研究院 NHRI:Item 3990099045/9011
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    題名: Anti-enterovirus compounds
    作者: Chern, JH;Shia, KS;Shih, SR;Hsu, TA;Tai, CL
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: This invention features, among others, a pyrazolopyrimidine compound of formula (A): | | A is (CH | | 2 | ) | q | --CHR | a | R | b | ; each of R | 1 | and R | 2 | , independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R | 1 | and R | 2 | taken together is (CH | 2 | ) | r | ; each of R | 3 | and R | 4 | , independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R | 5 | , R | a | , and R | b | , independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR', SR, S(O)R, S(O)OR, NRR', NR(O)CR', NRC(O) OR', or NRC(O)NR'R" each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R', and R", independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4. | This invention features, among others, a pyrazolopyrimidine compound of formula (A):A is (CH2)q-CHR<a>R<b>; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, R<a>, and R<b>, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR', SR, S(O)R, S(O)OR, NRR', NR(O)CR', NRC(O)OR', or NRC(O)NR'R''; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R', and R'', independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.
    日期: 2004-11-09
    關聯: US6815444B2/2004-11-09
    Link to: http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6815444&KC=B2
    顯示於類別:[陳志豪] 專利
    [夏克山] 專利
    [徐祖安] 專利

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