國家衛生研究院 NHRI:Item 3990099045/9010

NHRI > Institute of Biotechnology and Pharmaceutical Research > Chiung-Tong Chen > Patents > Item 3990099045/9010

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9010

Title:	Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
Authors:	Tong, CC;Jen, CS;Chu, HM;Ren, HD;Tai, LW;Chung, LC
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formula, each R1 is independently isoxazolyl, thiazolyl, isothiazolyl, 1, 3, 4-thiadiazolyl, 1, 3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R5; or when taken together with R2 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R2 is independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R5; or when taken together with R1 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R3 is independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R5. Each R4 is independently H, NO2, halo, CN, R7, OR7, CO2R7, SR7, NR7R 7, C(O)R7, C(O)NR7R7, OC(O)R7, S(O)2R7, S(O)2NR7R7, NR 7C(O)NR7R7, NR7C(O)R7, NR 7(COOR7), NR7S(O)2NR7R7, NR7S(O)2R7, or S(O)2OR7.
Date:	2005-06-07
Relation:	US6903104B2/2005-06-07
Link to:	http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6903104&KC=B2
Appears in Collections:	[Chiung-Tong Chen] Patents [Shu-Jung Chen(1998-2001)] Patents [Ming-Chu Hsu(1997-2001)] Patents

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