國家衛生研究院 NHRI:Item 3990099045/8989
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    題名: Transgenic animal for screening therapeutic agents for brain tumors
    作者: Chiu, IM
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: A non-human transgenic mammal whose genome comprises a transgene, which transgene comprises a promoter operably linked to a DNA fragment, wherein: the promoter comprises the nuclear factor binding region of the RR2 cis acting element of an FGF1B promoter; the DNA fragment comprises a sequence encoding the SV40 large T antigen; and the mammal comprises a tumor, the cells of which lack immunodetectable levels of glial fibrillary acidic protein, S-100, synaptophysin and neuron-specific enolase. Such a transgenic animal may be used in screening method for the identification of therapeutic agents useful in brain or tumor therapy.
    日期: 2008-09-03
    關聯: EP1221283B1/2008-09-03
    Link to: http://v3.espacenet.com/publicationDetails/biblio?CC=EP&NR=1221283&KC=B1
    顯示於類別:[邱英明] 專利

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