本發明係關於一種轉殖基因動物，其在基因組中包含編碼一或多種報導蛋白之聚核苷酸，以及單核細胞趨化蛋白-1(MCP-1)啟動子，其中該一或多種報導蛋白是在該MCP-1啟動子之控制下表現。本發明亦提供一種用於在體內監測MCP-1之內源性表現的方法，其可用於辨識MCP-1表現之調控劑或抗發炎劑。The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under the control of the MCP-1 promoter. A method for monitoring endogenous expression of MCP-1in vivo is also provided, which is useful for identifying a regulator of the expression of MCP-1 or an anti-inflammatory agent.
