一種改善脊髓損傷後肢體功能恢復的控制釋放多藥製劑配方，包括：a)一第一項組成物包含一第一項生物活性劑，其包覆於一第一項聚合物粒子中；b)一第二項組成物包含一第二項生物活性劑的，其包覆於一第二項聚合物粒子中，該第二項聚合物粒子包覆於第一項聚合物粒子中；c)亦可加上一第三項組成物包含一第三項生物活性劑，其包覆於第一或第二項聚合物粒子中，其中該第二項組成物之釋放順序須在第一項組成物之後，第一項生物活性劑為一神經營養因子，第二項生物活性劑則為一膠原蛋白合成抑制劑，第三項生物活性劑係選自由環腺酶單磷酸、一腺苷酸環化酶活化劑和一Rho抑制劑所組成的組群。A controlled release multidrug formulation for improving locomotor recovery after spinal cord injury comprising: (a) a first composition comprising a first bioactive agent, encapsulated within a first polymeric particle; (b) a second composition comprising a second bioactive agent, encapsulated within a second polymeric particle, wherein the second polymeric particle is encapsulated within the first polymeric particle; and (c) a third composition comprising a third bioactive agent, encapsulated within either the first or the second polymeric particle, wherein the second composition is released subsequently to the release of the first composition, and wherein the first bioactive agent is a neurotrophic factor, the second bioactive agent is a collagen synthesis inhibitor, and the third bioactive agent is selected from the group consisting of cyclic AMP (cAMP), an adenylate cyclase activator and a Rho inhibitor.
