國家衛生研究院 NHRI:Item 3990099045/8952
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    题名: Method for making a ligand-quantum dot conjugate
    作者: Lin, SY;Lo, LW;Yang, CS
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer; (2) adding into the solution a ligand; and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate.
    日期: 2012-07-10
    關聯: US8216549B2/2012-07-10
    Link to: http://v3.espacenet.com/publicationDetails/biblio?CC=US&NR=8216549&KC=B2
    显示于类别:[林淑宜] 專利
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