Systems and methods are provided for positioning a therapeutic device relative to a target displaced on a platform. A base member has a first track extending along a length of the platform for defining a first pathway for translating the therapeutic device relative to the target. A curved frame is slidably mounted on the base member through the first track. The curved frame has a second track along an interior wall of the curved frame for defining a second pathway for translating the therapeutic device relative to the target. A housing is disposed in the second track of the curved frame and configured to receive the therapeutic device. The housing is extendible at least along a radial direction of the curved frame for defining a third pathway for translating the therapeutic device relative to the target. Applications of the systems and methods may include image-guided thermal therapy.