本發明揭露單離之多肽，其含有嚴重急性呼吸道症候群(SARS)冠狀病毒(CoV)棘蛋白質（簡稱S蛋白質），以及上述多肽之功能等價物。本發明亦揭露單離之編碼上述多肽的核酸，與其相關之表現載體、宿主細胞、抗體、以及組合物。同時揭露生產上述多肽之方法，診斷冠狀病毒感染之方法，以及鑑定治療冠狀病毒感染之測試化合物的方法。 Isolated polypeptides containing fragments of SARS CoV S protein and functional equivalents thereof. Also disclosed are isolated nucleic acids encoding the polypeptides, related expression vectors, related host cells, related antibodies, and related compositions. Methods of producing the polypeptide, diagnosing infection with a coronavirus, and identifying a test compound for treating infection with a coronavirus are also disclosed.
