國家衛生研究院 NHRI:Item 3990099045/8834
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    题名: Low-normal serum potassium is associated with an increased risk of cardiovascular and all-cause death in community-based elderly
    作者: Lai, YH;Leu, HB;Yeh, WT;Chang, HY;Pan, WH
    贡献者: Division of Health Services and Preventive Medicine
    摘要: BACKGROUND/PURPOSE: Several studies have already reported that serum potassium (SK) correlated inversely with adverse events among patients with preexisting cardiovascular disease and impaired renal function; less is known about the prognostic value of SK at the normal range in community-based elderly individuals. OBJECTIVE: This study aimed to examine whether low normal SK value was associated with cardiovascular and all-cause mortalities in elderly people. METHODS: A prospective study was conducted using two independent elderly Taiwanese community cohorts that included 2065 individuals with relatively normal SK values (2.8-5.6 mmol/L). The participants were grouped as follows: low (2.8-3.4 mmol/L), low-normal SK (3.5-3.8 mmol/L), normal (3.9-4.4 mmol/L), and high-normal SK (4.5-5.6 mmol/L). Proportional hazards model was applied to compare the association between SK concentration groups and mortality. RESULTS: The relationship between baseline SK and all-cause and cardiovascular mortality was U-shaped, with the lowest mortality rates observed in patients with SK levels of 3.9-4.4 mmol/L. The low-normal SK group had significantly higher risks of all-cause (hazard ratio, 1.3; 95% confidence interval, 1.0-1.6) and cardiovascular mortality (hazard ratio, 1.6; 95% confidence interval, 1.1-2.3) than the normal SK group. The high-normal SK group had higher but nonsignificant risk compared to the normal group. CONCLUSION: Our findings suggest that low-normal SK may be used as a marker of poor survival for elderly outpatient cares.
    日期: 2015-06
    關聯: Journal of the Formosan Medical Association. 2015 Jun;114(6):517-525.
    Link to: http://dx.doi.org/10.1016/j.jfma.2015.01.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000357346400007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930413448
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