國家衛生研究院 NHRI:Item 3990099045/8830
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    題名: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway
    作者: Chen, JC;Chen, YJ;Lin, CY;Fong, YC;Hsu, CJ;Tsai, CH;Su, JL;Tang, CH
    貢獻者: National Institute of Cancer Research
    摘要: Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration. Exogenous AR markedly increased cell migration by transactivation of α6β1 integrin expression. A neutralizing α6β1 integrin antibody can abolish AR-induced cell motility. Knockdown of AR inhibits metastasis of cells to the lung in vivo. Furthermore, elevated AR expression is positively correlated with α6β1 integrin levels and higher grades in patients. These findings can potentially serve as biomarker and therapeutic approach for controlling chondrosarcoma metastasis.
    日期: 2015-05
    關聯: Oncotarget. 2015 May;6(13):11434-11446.
    Link to: http://dx.doi.org/10.18632/oncotarget.3397
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000359006400059
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929645751
    顯示於類別:[蘇振良] 期刊論文

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